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2010/2011 Studentship Recipients

Randi Woodbeck, University of Northern British Columbia

Supervisor: Dr. Chow Lee, Dept. of Chemistry, University of Northern BC

Project Title

Identification and characterization of novel human endoribonucleases with implications for cancer gene therapy.

Project Overview

This project aims to identify a special class of molecules with the ability to destroy genes that cause cancer. Only a handful of these molecules have been identified and well-studied, but evidence suggests that there are a great deal more that exist. A large number of molecules have been identified with the specific ability to destroy and therefore inactivate genes, and a list of promising candidates has been developed. This research will perform further studies on these candidate molecules. These studies will be an important step for future development of new anti-cancer therapy using these molecules.

 

Sandra Unger, Simon Fraser University

Supervisor: Dr. Aly Karsan, Genome Sciences Centre, BCCRC 

Project Title

Identification of the Notch co-factor RBPJ as a potential tumour surpressor in human breast cancer.

Project Overview

This project will focus on the protein RBPJ and its potential role as a tumour suppressor. Breast cancer samples will be stain prepared and analyzed to determine if they contain a significantly lower amount of RBPJ than normal breast tissue samples. The effects of different levels of expression of RBPJ on tumour growth and size will also be studied.